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Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway that modulates cellular redox homeostasis via the regeneration of NADPH. G6PD-deficient cells have a reduced ability to induce the innate immune response, thus increasing host susceptibility to path...

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מידע ביבליוגרפי
הוצא לאור ב:	Redox Biol
Main Authors:	Yen, Wei-Chen, Wu, Yi-Hsuan, Wu, Chih-Ching, Lin, Hsin-Ru, Stern, Arnold, Chen, Shih-Hsiang, Shu, Jwu-Ching, Tsun-Yee Chiu, Daniel
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2019
נושאים:	Research Paper
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6854078/ https://ncbi.nlm.nih.gov/pubmed/31707353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101363
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Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

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