NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes

Nucleophosmin (NPM1) is frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation, which creates a nuclear export signal, is characterized by cytoplasmic localization and leukemogeni...

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Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Darracq, Anaïs, Pak, Helen, Bourgoin, Vincent, Zmiri, Farah, Dellaire, Graham, Affar, El Bachir, Milot, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853375/
https://ncbi.nlm.nih.gov/pubmed/31675375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008463
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