Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata

Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study. FKS mutants carrying specific mutations found in L74 were reconstructed by the Alt-R CR...

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Veröffentlicht in:Emerg Microbes Infect
Hauptverfasser: Hou, Xin, Healey, Kelley R., Shor, Erika, Kordalewska, Milena, Ortigosa, Cristina Jiménez, Paderu, Padmaja, Xiao, Meng, Wang, He, Zhao, Ying, Lin, Li-Yan, Zhang, Yan-Hai, Li, Yong-Zhe, Xu, Ying-Chun, Perlin, David S., Zhao, Yanan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853239/
https://ncbi.nlm.nih.gov/pubmed/31711370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2019.1684209
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