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Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells
Bile acids (BAs) are recognised as the causative agents of toxicity in drug-induced cholestasis (DIC). Research in isolated mitochondria and HepG2 cells have demonstrated BA-mediated mitochondrial dysfunction as a key mechanism of toxicity in DIC. However, HepG2 cells are of limited suitability for...
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| Publicado no: | Toxicol In Vitro |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Pergamon Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6853172/ https://ncbi.nlm.nih.gov/pubmed/31288073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2019.104595 |
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