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A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding
The development of a fluorescent LCK inhibitor that exhibits favourable solvatochromic properties upon binding the kinase is described. Fluorescent properties were realised through the inclusion of a prodan‐derived fluorophore into the pharmacophore of an ATP‐competitive kinase inhibitor. Fluorescen...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6851755/ https://ncbi.nlm.nih.gov/pubmed/31411364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201909536 |
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