ATRX in-frame fusion neuroblastoma is sensitive to EZH2 inhibition via modulation of neuronal gene signatures

ATRX alterations occur at high frequency in neuroblastoma of adolescents and young adults. Particularly intriguing are the large N-terminal deletions of ATRX that generate in-frame fusion (IFF) proteins devoid of key chromatin interaction domains, while retaining the SWI/SNF-like helicase region. We...

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Publicado no:Cancer Cell
Main Authors: Qadeer, Zulekha A., Valle-Garcia, David, Hasson, Dan, Sun, Zhen, Cook, April, Nguyen, Christie, Soriano, Aroa, Ma, Anqi, Griffiths, Lyra M., Zeineldin, Maged, Filipescu, Dan, Jubierre, Luz, Chowdhury, Asif, Deevy, Orla, Chen, Xiang, Finkelstein, David B., Bahrami, Armita, Stewart, Elizabeth, Federico, Sara, Gallego, Soledad, Dekio, Fumiko, Fowkes, Mary, Meni, David, Maris, John M., Weiss, William A., Roberts, Stephen S., Cheung, Nai-Kong V., Jin, Jian, Segura, Miguel F., Dyer, Michael A., Bernstein, Emily
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851493/
https://ncbi.nlm.nih.gov/pubmed/31631027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.09.002
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