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CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor

Volume-regulated anion channels (VRACs) encoded by the leucine-rich repeat containing 8 (LRRC8) gene family play critical roles in myriad cellular processes and might represent druggable targets. The dearth of pharmacological compounds available for studying VRAC physiology led us to perform a high-...

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Detalles Bibliográficos
Publicado en:Am J Physiol Cell Physiol
Main Authors: Figueroa, Eric E., Kramer, Meghan, Strange, Kevin, Denton, Jerod S.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850990/
https://ncbi.nlm.nih.gov/pubmed/31390227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00281.2019
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