A phase 1 study of ADI-PEG 20 and modified FOLFOX6 in patients with advanced hepatocellular carcinoma and other gastrointestinal malignancies

PURPOSE: Arginine depletion interferes with pyrimidine metabolism as well as DNA damage repair pathways. Preclinical data indicates that pairing pegylated arginine deiminase (ADI-PEG 20) with fluoropyrimidines or platinum enhances cytotoxicity in vitro and in vivo in arginine auxotrophs. METHODS: Th...

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Veröffentlicht in:Cancer Chemother Pharmacol
Hauptverfasser: Harding, James J., Do, Richard K., Dika, Imane El, Hollywood, Ellen, Uhlitskykh, Khrystyna, Valentino, Emily, Wan, Peter, Hamilton, Casey, Feng, Xiaoxing, Johnston, Amanda, Bomalaski, John, Li, Chien-Feng, O’Reilly, Eileen M., Abou-Alfa, Ghassan K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850802/
https://ncbi.nlm.nih.gov/pubmed/29971467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-018-3635-3
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