A phase 1 study of ADI-PEG 20 and modified FOLFOX6 in patients with advanced hepatocellular carcinoma and other gastrointestinal malignancies

PURPOSE: Arginine depletion interferes with pyrimidine metabolism as well as DNA damage repair pathways. Preclinical data indicates that pairing pegylated arginine deiminase (ADI-PEG 20) with fluoropyrimidines or platinum enhances cytotoxicity in vitro and in vivo in arginine auxotrophs. METHODS: Th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Harding, James J., Do, Richard K., Dika, Imane El, Hollywood, Ellen, Uhlitskykh, Khrystyna, Valentino, Emily, Wan, Peter, Hamilton, Casey, Feng, Xiaoxing, Johnston, Amanda, Bomalaski, John, Li, Chien-Feng, O’Reilly, Eileen M., Abou-Alfa, Ghassan K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850802/
https://ncbi.nlm.nih.gov/pubmed/29971467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-018-3635-3
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados