Phase I study of ADI‐PEG20 plus low‐dose cytarabine for the treatment of acute myeloid leukemia

Most acute myeloid leukemia (AML) cells are argininosuccinate synthetase‐deficient. Pegylated arginine deiminase (ADI‐PEG20) monotherapy depletes circulating arginine, thereby selectively inducing tumor cell death. ADI‐PEG20 was shown to induce complete responses in ~10% of relapsed/refractory or po...

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Bibliografiske detaljer
Udgivet i:Cancer Med
Main Authors: Tsai, Hui‐Jen, Hsiao, Hui‐Hua, Hsu, Ya‐Ting, Liu, Yi‐Chang, Kao, Hsiao‐Wen, Liu, Ta‐Chih, Cho, Shih‐Feng, Feng, Xiaoxing, Johnston, Amanda, Bomalaski, John S., Kuo, Ming‐Chung, Chen, Tsai‐Yun
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Clinical Cancer Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085967/
https://ncbi.nlm.nih.gov/pubmed/33787078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3871
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