Phase I study of ADI‐PEG20 plus low‐dose cytarabine for the treatment of acute myeloid leukemia

Most acute myeloid leukemia (AML) cells are argininosuccinate synthetase‐deficient. Pegylated arginine deiminase (ADI‐PEG20) monotherapy depletes circulating arginine, thereby selectively inducing tumor cell death. ADI‐PEG20 was shown to induce complete responses in ~10% of relapsed/refractory or po...

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Foilsithe in:Cancer Med
Main Authors: Tsai, Hui‐Jen, Hsiao, Hui‐Hua, Hsu, Ya‐Ting, Liu, Yi‐Chang, Kao, Hsiao‐Wen, Liu, Ta‐Chih, Cho, Shih‐Feng, Feng, Xiaoxing, Johnston, Amanda, Bomalaski, John S., Kuo, Ming‐Chung, Chen, Tsai‐Yun
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2021
Ábhair:
Clinical Cancer Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085967/
https://ncbi.nlm.nih.gov/pubmed/33787078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3871
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