Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens?

AIMS: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimens. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy specimens. METHODS AND RESULTS: Using the Dutch pathology registry (PALGA), surgi...

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Publicat a:Histopathology
Autors principals: Derks, Jules L, Dingemans, Anne‐Marie C, van Suylen, Robert‐Jan, den Bakker, Michael A, Damhuis, Ronald A M, van den Broek, Esther C, Speel, Ernst‐Jan, Thunnissen, Erik
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850184/
https://ncbi.nlm.nih.gov/pubmed/30485478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/his.13800
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