Large cell neuroendocrine carcinoma with a solitary brain metastasis and low Ki-67: a unique subtype

INTRODUCTION: Stage IV large cell neuroendocrine carcinoma (LCNEC) of the lung generally presents as disseminated and aggressive disease with a Ki-67 proliferation index (PI) 40–80%. LCNEC can be subdivided in two main subtypes: the first harboring TP53/RB1 mutations (small-cell lung carcinoma (SCLC...

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Detalhes bibliográficos
Publicado no:Endocr Connect
Main Authors: Hermans, B C M, Derks, J L, Groen, H J M, Stigt, J A, van Suylen, R J, Hillen, L M, van den Broek, E C, Speel, E J M, Dingemans, A-M C
Formato: Artigo
Idioma:Inglês
Publicado em: Bioscientifica Ltd 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933830/
https://ncbi.nlm.nih.gov/pubmed/31751303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EC-19-0372
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