Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens?

AIMS: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimens. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy specimens. METHODS AND RESULTS: Using the Dutch pathology registry (PALGA), surgi...

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Detalhes bibliográficos
Publicado no:Histopathology
Main Authors: Derks, Jules L, Dingemans, Anne‐Marie C, van Suylen, Robert‐Jan, den Bakker, Michael A, Damhuis, Ronald A M, van den Broek, Esther C, Speel, Ernst‐Jan, Thunnissen, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850184/
https://ncbi.nlm.nih.gov/pubmed/30485478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/his.13800
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