SMAD4 alteration associates with invasive‐front pathological markers and poor prognosis in colorectal cancer

AIMS: SMAD4 acts as a tumour suppressor, and the loss of SMAD4 is associated with poor prognosis in colorectal cancer (CRC) patients. Although next‐generation sequencing (NGS) enabled us to detect numerous genetic alterations in a single assay, the clinical significance of SMAD4 alteration detected...

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Detalhes bibliográficos
Publicado no:Histopathology
Main Authors: Oyanagi, Hidehito, Shimada, Yoshifumi, Nagahashi, Masayuki, Ichikawa, Hiroshi, Tajima, Yosuke, Abe, Kaoru, Nakano, Masato, Kameyama, Hitoshi, Takii, Yasumasa, Kawasaki, Takashi, Homma, Kei‐Ichi, Ling, Yiwei, Okuda, Shujiro, Takabe, Kazuaki, Wakai, Toshifumi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6849740/
https://ncbi.nlm.nih.gov/pubmed/30636020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/his.13805
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