HO-1 promotes resistance to an EZH2 inhibitor through the pRB-E2F pathway: correlation with the progression of myelodysplastic syndrome into acute myeloid leukemia

BACKGROUND: Myelodysplastic syndrome (MDS) can progress to acute myeloid leukemia (AML), and conventional chemotherapy (decitabine) does not effectively inhibit tumor cells. Enhancer of zeste homologue 2 (EZH2) and Heme oxygenase-1 (HO-1) are two key factors in patients resistance and deterioration....

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Dettagli Bibliografici
Pubblicato in:J Transl Med
Autori principali: He, Zhengchang, Zhang, Siyu, Ma, Dan, Fang, Qin, Yang, Liping, Shen, Shaoxian, Chen, Ying, Ren, Lingli, Wang, Jishi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6849246/
https://ncbi.nlm.nih.gov/pubmed/31711520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-2115-9
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