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Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2

Nuclear factor erythroid 2-related factor 2 (Nrf2, also called NFE2L2) plays an important role in cancer chemoresistance. However, little is known about the role of Nrf2 in tumor mutation burden and the effect of Nrf2 in modulating DNA mismatch repair (MMR) gene in acute myeloid leukemia (AML). Here...

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Библиографические подробности
Опубликовано в: :Cell Death Dis
Главные авторы: Liu, Ping, Ma, Dan, Wang, Ping, Pan, Chengyun, Fang, Qin, Wang, Jishi
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790830/
https://ncbi.nlm.nih.gov/pubmed/33414469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03331-x
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