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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
Recent experiments have demonstrated that the Polycomb group (PcG) gene EZH2 is highly expressed in metastatic prostate cancer and in lymphomas. EZH2 is a component of the PRC2 histone methyltransferase complex, which also contains EED and SUZ12 and is required for the silencing of HOX gene expressi...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC213796/ https://ncbi.nlm.nih.gov/pubmed/14532106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg542 |
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