EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

Recent experiments have demonstrated that the Polycomb group (PcG) gene EZH2 is highly expressed in metastatic prostate cancer and in lymphomas. EZH2 is a component of the PRC2 histone methyltransferase complex, which also contains EED and SUZ12 and is required for the silencing of HOX gene expressi...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Bracken, Adrian P., Pasini, Diego, Capra, Maria, Prosperini, Elena, Colli, Elena, Helin, Kristian
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2003
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC213796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14532106/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg542
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