Binding and structural analyses of potent inhibitors of the human Ca(2+)/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) acts as a signaling hub, receiving signals from various regulatory pathways and decoding them via phosphorylation of downstream protein kinases - such as AMPK (AMP-activated protein kinase) and CAMK types I and IV. CAMKK2 relevance is hig...

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Publicat a:Sci Rep
Autors principals: Profeta, Gerson S., dos Reis, Caio V., Santiago, André da S., Godoi, Paulo H. C., Fala, Angela M., Wells, Carrow I., Sartori, Roger, Salmazo, Anita P. T., Ramos, Priscila Z., Massirer, Katlin B., Elkins, Jonathan M., Drewry, David H., Gileadi, Opher, Couñago, Rafael M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848146/
https://ncbi.nlm.nih.gov/pubmed/31712618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52795-1
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