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Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2

[Image: see text] Vaccinia-related kinases 1 and 2 (VRK1 and VRK2) are human Ser/Thr protein kinases associated with increased cell division and neurological disorders. Nevertheless, the cellular functions of these proteins are not fully understood. Despite their therapeutic potential, there are no...

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Publicat a:ACS Med Chem Lett
Autors principals: Serafim, Ricardo A. M., de Souza Gama, Fernando H., Dutra, Luiz A., dos Reis, Caio V., Vasconcelos, Stanley N. S., da Silva Santiago, André, Takarada, Jéssica E., Di Pillo, Fúlvia, Azevedo, Hatylas, Mascarello, Alessandra, Elkins, Jonathan M., Massirer, Katlin B., Gileadi, Opher, Guimarães, Cristiano R. W., Couñago, Rafael M.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746079/
https://ncbi.nlm.nih.gov/pubmed/31531195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00082
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