STEM-22. TARGETING PYRIMIDINE SYNTHESIS ACCENTUATES MOLECULAR THERAPY RESPONSE IN GLIOBLASTOMA STEM CELLS

Glioblastoma stem cells (GSCs) reprogram glucose metabolism by hijacking high-affinity glucose uptake to survive in a nutritionally dynamic microenvironment. Here, we trace metabolic aberrations in GSCs to link core genetic mutations in glioblastoma to dependency on de novo pyrimidine synthesis. Tar...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Yang, Kailin, Wang, Xiuxing, Wu, Qiulian, Kim, Leo, Morton, Andrew, Gimple, Ryan, Prager, Briana, Shi, Yu, Zhou, Wenchao, Bhargava, Shruti, Zhu, Zhe, Jiang, Li, Tao, Weiwei, Qiu, Zhixin, Zhao, Linjie, Zhang, Guoxing, Li, Xiqing, Agnihotri, Sameer, Mischel, Paul, Mack, Stephen, Bao, Shideng, Rich, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847913/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.995
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