PATH-04. INFLUENCE OF INDIVIDUAL CpG METHYLATION STATUS OF THE MGMT PROMOTOR ON OUTCOME IN ADULT PATIENTS WITH GLIOBLASTOMA MULTIFORME RECEIVING ALKYLATING AGENT TREATMENT

BACKGROUND: Methylation of O-6-methylguanine-DNA-methyltransferase (MGMT) promotor causes gene silencing and has been associated with a favourable prognosis in patients with glioblastoma multiforme (GBM) receiving alkylating chemotherapy. However, analysis of MGMT promotor methylation is usually rep...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Siller, Sebastian, Lauseker, Michael, Giese, Armin, Tonn, Joerg-Christian, Niyazi, Karim-Maximilian, Thon, Niklas, Suchorska, Bogdana, Kreth, Friedrich-Wilhelm
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Molecular Pathology and Classification - Adult and Pediatric
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847860/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.600
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