CSIG-25. MTAP LOSS COMPROMISES DNA DAMAGE RESPONSE IN GBM CELLS

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic alterations in glioblastomas (GBMs), occurring in about half of all patients. Here, we demonstrated that MTAP loss compromises the proteostasis of genomic stability guardian, H2AX, via disrupting a si...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neuro Oncol
Egile Nagusiak: Du, Changzheng, Hansen, Landon, Singh, Simranjit, Roso, Kristen, Greer, Paula, He, Yiping
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2019
Gaiak:
Cell Signaling and Signaling Pathways
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847699/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.195
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