CSIG-25. MTAP LOSS COMPROMISES DNA DAMAGE RESPONSE IN GBM CELLS

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic alterations in glioblastomas (GBMs), occurring in about half of all patients. Here, we demonstrated that MTAP loss compromises the proteostasis of genomic stability guardian, H2AX, via disrupting a si...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Du, Changzheng, Hansen, Landon, Singh, Simranjit, Roso, Kristen, Greer, Paula, He, Yiping
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Cell Signaling and Signaling Pathways
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847699/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.195
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