EXTH-58. INHIBITION OF DNA TOPOISOMERASE 1 AND POLY(ADP-RIBOSE) POLYMERASE SYNERGISTICALLY INDUCES CELL DEATH IN GLIOBLASTOMA WITH PTEN LOSS

BACKGROUND: Glioblastoma is known for its aggressive behavior and resistance to most available treatments. Topoisomerase 1 (Top1) functions by relaxing DNA supercoiling to facilitate replication. The novel Top1 inhibitor, LMP400, traps the enzyme and prevents its normal function, particularly in hig...

全面介紹

Na minha lista:
書目詳細資料
發表在:Neuro Oncol
Main Authors: Butler, Madison, Su, Yu-Ting, Hwang, Lee, Marzi, Laetitia, Gilbert, Mark, Pommier, Yves, Wu, Jing
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
主題:
Experimental Therapeutics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847599/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.389
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍