EXTH-58. INHIBITION OF DNA TOPOISOMERASE 1 AND POLY(ADP-RIBOSE) POLYMERASE SYNERGISTICALLY INDUCES CELL DEATH IN GLIOBLASTOMA WITH PTEN LOSS

BACKGROUND: Glioblastoma is known for its aggressive behavior and resistance to most available treatments. Topoisomerase 1 (Top1) functions by relaxing DNA supercoiling to facilitate replication. The novel Top1 inhibitor, LMP400, traps the enzyme and prevents its normal function, particularly in hig...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Butler, Madison, Su, Yu-Ting, Hwang, Lee, Marzi, Laetitia, Gilbert, Mark, Pommier, Yves, Wu, Jing
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847599/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.389
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