Myocardial protection by selective poly(ADP-ribose) polymerase inhibitors

During ischemia-reperfusion, reactive oxygen species are generated along the mitochondrial respiratory chain and induce lipid peroxidation, protein oxidation and DNA damage. Single-strand DNA breaks are the most potent activators of poly(ADP-ribose) polymerase (PARP); prolonged action of PARP culmin...

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Autori principali: Kovacs, Krisztina, Toth, Ambrus, Deres, Peter, Kalai, Tamas, Hideg, Kalman, Sumegi, Balazs
Natura: Artigo
Lingua:Inglês
Pubblicazione: Pulsus Group Inc 2004
Soggetti:
Experimental Cardiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716257/
https://ncbi.nlm.nih.gov/pubmed/19641691
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