CBMT-39. TARGETING METABOLIC PATHWAYS IN HYPOXIA FOR GLIOBLASTOMA

BACKGROUND: Metabolic adaptation to hypoxia is a crucial consideration in combating anti-angiogenic resistance. We previously explored the potential of targeting the peroxisomal fatty acid oxidation (FAO) pathway and observed higher potency to peroxisomal FAO inhibitor thioridazine in hypoxia in vit...

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Publicado en:Neuro Oncol
Autores principales: Gruslova, Aleksandra, Lodi, Alessia, Li, Mengxing, Zhou, Mei, Garcia, Michael, Tiziani, Stefano, Brenner, Andrew, Caflisch, Laura
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Cell Biology and Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847540/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.161
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