EXTH-43. DYNAMIC MULTI-OMICS ANALYSIS OF MLN4924-TREATED GLIOBLASTOMA CELLS REVEALS ABSENCE OF PTEN AS A CANDIDATE DRIVER OF NEDDYLATION INHIBITION RESISTANCE

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor and calls for novel therapeutic development. The neddylation pathway may be a therapeutic target, as global over activation of neddylation has been found in GBM patients and has correlated with shorter patient survival. Analogous t...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Taylor, Brett, Ferdosi, Shayesteh, Bybee, Rita, Tang, Nanyun, Peng, Sen, Garcia-Mansfield, Krystine, David-Dirgo, Victoria, Sharma, Ritin, Pirrotte, Patrick, Berens, Michael, Dhruv, Harshil
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847261/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.375
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