CSIG-31. ALTERNATIVE RECEPTOR TYROSINE KINASE SIGNALING AS A RESISTANCE MECHANISM TO ERK INHIBITION IN HIGH-GRADE GLIOMAS

Pediatric High-Grade Gliomas (PHGG), which include Diffuse Midline Gliomas (DMG), are a leading cause of brain tumor death in children. Our recent work has identified extracellular signal-regulated kinase 5 (ERK5) as a critical mediator of cell survival in PHGG. Suppression of ERK5 genetically or ph...

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Foilsithe in:Neuro Oncol
Main Authors: Stanton, Ann-Catherine, Koncar, Robert, Golbourn, Brian, Wassell, Michelle, Agrawal, Nishant, Dey, Brittany, Myers, Max, Mack, Stephen, Pollack, Ian, Agnihotri, Sameer
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2019
Ábhair:
Cell Signaling and Signaling Pathways
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847247/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.201
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