CSIG-21. DE-ORPHANIZING GPR133 - AN ADHESION GPCR REQUIRED FOR GLIOBLASTOMA PROGRESSION

We previously found GPR133 (ADGRD1), an orphan adhesion GPCR, is de novo expressed in glioblastoma (GBM) and enriched in patient-derived glioblastoma stem cells (GSCs). Knockdown of GPR133 reduces GBM cell proliferation and tumorsphere formation, and abolishes orthotopic tumor initiation in vivo in...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Frenster, Joshua, Erdjument-Bromage, Hediye, Stephan, Gabriele, Chidambaram, Shravanthi, Alghamdi, Abdulhakeem, Bready, Devin, Straeter, Norbert, Liebscher, Ines, Schoeneberg, Torsten, Neubert, Thomas, Placantonakis, Dimitris
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Cell Signaling and Signaling Pathways
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847160/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.191
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