Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling

GPR133 (ADGRD1), an adhesion G protein–coupled receptor (GPCR) whose canonical signaling activates G(αS)-mediated generation of cytosolic cAMP, has been shown to be necessary for the growth of glioblastoma (GBM), a brain malignancy. The extracellular N terminus of GPR133 is thought to be autoproteol...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Frenster, Joshua D., Stephan, Gabriele, Ravn-Boess, Niklas, Bready, Devin, Wilcox, Jordan, Kieslich, Bjoern, Wilde, Caroline, Sträter, Norbert, Wiggin, Giselle R., Liebscher, Ines, Schöneberg, Torsten, Placantonakis, Dimitris G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215292/
https://ncbi.nlm.nih.gov/pubmed/34022221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100798
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados