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The mechanism of eukaryotic CMG helicase activation
The initiation of eukaryotic DNA replication occurs in two discrete stages(1): the minichromosome maintenance (MCM) complex is first loaded as a head-to-head double hexamer (DH) encircling duplex origin DNA during G1 phase; ‘firing factors’ then convert each DH into two active CMG (Cdc45-MCM-GINS) h...
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| Pubblicato in: | Nature |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6847044/ https://ncbi.nlm.nih.gov/pubmed/29489749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25787 |
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