PDTM-28. AN OTX2-PAX3 SIGNALLING AXIS REGULATES GROUP 3 MEDULLOBLASTOMA CELL FATE

The majority of Group 3 medulloblastomas (MB) exhibit amplification or increased expression of OTX2. OTX2 is primarily known as an oncogenic driver of tumor growth and cell cycle progression in Group 3 MB; however, its role as a repressor of differentiation is poorly characterized. Therefore, we uti...

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Vydáno v:Neuro Oncol
Hlavní autoři: Zagozewski, Jamie, Shahriary, Ghazaleh, Morrison, Ludivine, Stromecki, Margaret, Fresnoza, Agnes, Palidwor, Gareth, Porter, Christopher, Forget, Antoine, Ayrault, Olivier, Hawkins, Cynthia, Chan, Jennifer, Saulnier, Olivier, Vladoiu, Maria, Taylor, Michael, Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Pediatric Tumors
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846908/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.804
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