DDIS-27. TARGETING ATP DOCKING AND P35/P25 BINDING OF CDK5 IN GLIOMA STEM CELLS USING SYNTHETIC INHIBITORS

The survival advantage of glioma stem cells (GSCs) represents a critical mechanism for growth, therapy resistance and recurrence in glioblastoma. So far, targeting GSCs has not been highly specific, since these cells co-opt the normal developmental signaling pathways. We have demonstrated that the a...

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Publicat a:Neuro Oncol
Autors principals: Mukherjee, Subhas, Schiltz, Gary, Clutter, Matt, Mishra, Rama, Olson, Cheryl, Dunder, Bilge, Sharma, Nitya, Markwell, Steven, Brat, Daniel
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Drug Discovery
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846902/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.278
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