PDTM-15. EMBRYONIC STEM CELL SIGNATURE DRIVES ATYPICAL TERATOID/RHABDOID TUMOR DEVELOPMENT IN HUMAN PLURIPOTENT STEM CELL-DERIVED TUMOR MODEL

BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT), which harbors SMARCB1 mutation and exhibits a characteristic histology of rhabdoid cells, has a poor prognosis because of the lack of effective treatment. METHODS: To investigate the pathogenesis of AT/RT, we establish human SMARCB1-deficient plu...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Arakawa, Yoshiki, Terada, Yukinori, Mineharu, Yohei, Miyamoto, Susumu, Yamada, Yasuhiro
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Pediatric Tumors
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846875/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.791
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