TB-01 HUMAN IPS CELL-DERIVED BRAIN TUMOR MODEL UNCOVERS THE EMBRYONIC STEM CELL SIGNATURE AS A KEY DRIVER IN ATYPICAL TERATOID/RHABDOID TUMOR

Atypical teratoid/rhabdoid tumor (AT/RT), which harbors SMARCB1 mutation and exhibits a characteristic histology of rhabdoid cells, has a poor prognosis because of the lack of effective treatments. We established human SMARCB1-deficient pluripotent stem cells (hPSCs), which enabled investigation of...

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Detalhes bibliográficos
Publicado no:Neurooncol Adv
Main Authors: Terada, Yukinori, Jo, Norihide, Arakawa, Yoshiki, Mineharu, Yohei, Yamada, Yasuhiro, Miyamoto, Susumu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213114/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz039.044
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