TMIC-15. HYPERACTIVATING THE HIPPO PATHWAY EFFECTOR TAZ DIFFERENTIALLY DISTORTS THE TUMOR MICROENVIRONMENT, PROMOTES TUMOR-ASSOCIATED NEUTROPHIL INFILTRATION, AND PHENOCOPIES MESENCHYMAL-GLIOBLASTOMA

Glioblastoma (GBM), the deadliest and most common adult brain malignancy, is molecularly and clinically heterogeneous. The most common subtype (both primary and recurrent), mesenchymal (MES)-GBM, has the worst prognosis and highest treatment resistance. MES-GBM exhibits hyperactive transcriptional c...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Yee, Patricia, Wei, Yiju, Liu, Zhijun, Guo, Hui, Manjibhai Vekariya, Umeshkumar, Anderson, Benjamin, Li, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Tumor Microenvironment
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846754/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1049
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