IMMU-30. UTILIZING A NOVEL MASS CYTOMETRY-BASED IMMUNOMONITORING PLATFORM FOR THE CHARACTERIZATION OF VACCINE-REACTIVE, EPITOPE-SPECIFIC CD8(+) T-CELLS IN HLA-A*0201(+) PATIENTS WITH K27M(+) DIFFUSE MIDLINE GLIOMAS

Diffuse midline glioma (DMG), including diffuse intrinsic pontine glioma (DIPG) constitutes up to 20% of pediatric brain cancer and has a median survival of less than one year. We have identified a novel HLA-A*02:01-restricted neoantigen epitope encompassing the H3.3K27M mutation and implemented a p...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Taitt, Jared, Watchmaker, Payal, Nejo, Takahide, Almeida, Neil, Okada, Kaori, Shahin, Maryam, Gilbert, Ryan, Mueller, Sabine, Okada, Hideho
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846708/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.522
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