AID–RNA polymerase II transcription-dependent deamination of IgV DNA

Activation-induced deoxycytidine deaminase (AID) initiates somatic hypermutation (SHM) in immunoglobulin variable (IgV) genes to produce high-affinity antibodies. SHM requires IgV transcription by RNA polymerase II (Pol II). A eukaryotic transcription system including AID has not been reported previ...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Pham, Phuong, Malik, Sohail, Mak, Chiho, Calabrese, Peter C, Roeder, Robert G, Goodman, Myron F
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Nucleic Acid Enzymes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846656/
https://ncbi.nlm.nih.gov/pubmed/31566237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz821
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