TMOD-40. IN VIVO EVALUATION OF O(6)-METHYLGUANINE-DNA-METHYLTRANSFERASE (MGMT) PROMOTER METHYLATION STATUS FOR DE NOVO GLIOBLASTOMA PATIENTS USING DEEP LEARNING FEATURES

BACKGROUND: High expression of O6-methylguanine-DNA methyltransferase (MGMT) in glioblastoma is associated with resistance to temozolomide, as tumor cells lacking MGMT activity are significantly more sensitive to the cytotoxic effects of temozolomide. The MGMT promoter methylation status (MGMTpms) i...

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Vydáno v:Neuro Oncol
Hlavní autoři: Rathore, Saima, Nasrallah, MacLean, Akbari, Hamed, Shukla, Gaurav, Bagley, Stephen, Watt, Christopher, Min Ha, Sung, Mamourian, Elizabeth, Sako, Chiharu, Binder, Zev, O’Rourke, Donald, Davatzikos, Christos
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Tumor Models
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846190/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1139
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