TMOD-40. IN VIVO EVALUATION OF O(6)-METHYLGUANINE-DNA-METHYLTRANSFERASE (MGMT) PROMOTER METHYLATION STATUS FOR DE NOVO GLIOBLASTOMA PATIENTS USING DEEP LEARNING FEATURES

BACKGROUND: High expression of O6-methylguanine-DNA methyltransferase (MGMT) in glioblastoma is associated with resistance to temozolomide, as tumor cells lacking MGMT activity are significantly more sensitive to the cytotoxic effects of temozolomide. The MGMT promoter methylation status (MGMTpms) i...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Rathore, Saima, Nasrallah, MacLean, Akbari, Hamed, Shukla, Gaurav, Bagley, Stephen, Watt, Christopher, Min Ha, Sung, Mamourian, Elizabeth, Sako, Chiharu, Binder, Zev, O’Rourke, Donald, Davatzikos, Christos
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Tumor Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846190/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1139
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