TMOD-40. IN VIVO EVALUATION OF O(6)-METHYLGUANINE-DNA-METHYLTRANSFERASE (MGMT) PROMOTER METHYLATION STATUS FOR DE NOVO GLIOBLASTOMA PATIENTS USING DEEP LEARNING FEATURES

BACKGROUND: High expression of O6-methylguanine-DNA methyltransferase (MGMT) in glioblastoma is associated with resistance to temozolomide, as tumor cells lacking MGMT activity are significantly more sensitive to the cytotoxic effects of temozolomide. The MGMT promoter methylation status (MGMTpms) i...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Rathore, Saima, Nasrallah, MacLean, Akbari, Hamed, Shukla, Gaurav, Bagley, Stephen, Watt, Christopher, Min Ha, Sung, Mamourian, Elizabeth, Sako, Chiharu, Binder, Zev, O’Rourke, Donald, Davatzikos, Christos
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
Tumor Models
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846190/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1139
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