NIMG-45. MULTIVARIATE PATTERN ANALYSIS OF DE NOVO GLIOBLASTOMA PATIENTS OFFERS IN VIVO EVALUATION OF O(6)-METHYLGUANINE-DNA-METHYLTRANSFERASE (MGMT) PROMOTER METHYLATION STATUS, COMPENSATING FOR INSUFFICIENT SPECIMEN AND ASSAY FAILURES

BACKGROUND: The promoter methylation status of the gene encoding for the repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) indicates increased efficacy of current standard of care therapy, which is concomitant adjuvant chemoradiotherapy with temozolomide. The MGMT promoter methylation stat...

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Published in:Neuro Oncol
Main Authors: Rathore, Saima, Bakas, Spyridon, Nasrallah, MacLean, Akbari, Hamed, Bagley, Stephen, Min Ha, Sung, Mamourian, Elizabeth, Watt, Christopher, Binder, Zev, O’Rourke, Donald, Davatzikos, Christos
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216259/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.771
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