AGE-ASSOCIATED INCREASE IN KYNURENINE SUPPRESSES AUTOPHAGY AND PROMOTES APOPTOSIS IN MESENCHYMAL STEM CELLS

The age-related increase of the tryptophan metabolite, kynurenine (KYN), has been associated with osteoporosis progression. Increased activity of by Indoleamine-(2,3)-dioxygenase(IDO), are responsible for the elevation of KYN levels in bone tissue. IDO activity is elevated with age and could be a pr...

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Udgivet i:Innov Aging
Main Authors: Kondrikov, Dmitry, Elmansi, Ahmed, Bragg, Robert T, Mobley, Tanner, mcGee-Lawrence, Meghan, Hamrick, Mark, Isales, Carlos, Hill, William D
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Session 835 (Poster)
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844752/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igz038.401
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