Blocking late stages of splicing quickly limits pre-spliceosome assembly in vivo

Pre-messenger RNA splicing involves multi-step assembly of the large spliceosome complexes that catalyse the two consecutive trans-esterification reactions, resulting in intron removal. There is evidence that proof-reading mechanisms monitor the fidelity of this complex process. Transcripts that fai...

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Bibliographische Detailangaben
Veröffentlicht in:RNA Biol
Hauptverfasser: Mendoza-Ochoa, Gonzalo I., Barrass, J. David, Maudlin, Isabella E., Beggs, Jean D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844569/
https://ncbi.nlm.nih.gov/pubmed/31671032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2019.1657788
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