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Cwc21p promotes the second step conformation of the spliceosome and modulates 3′ splice site selection
Pre-mRNA splicing involves two transesterification steps catalyzed by the spliceosome. How RNA substrates are positioned in each step and the molecular rearrangements involved, remain obscure. Here, we show that mutations in PRP16, PRP8, SNU114 and the U5 snRNA that affect this process interact gene...
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| Опубликовано в: : | Nucleic Acids Res |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4381068/ https://ncbi.nlm.nih.gov/pubmed/25740649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv159 |
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