Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes

Human CWC27 is an uncharacterized splicing factor and mutations in its gene are linked to retinal degeneration and other developmental defects. We identify the splicing factor CWC22 as the major CWC27 partner. Both CWC27 and CWC22 are present in published B(act) spliceosome structures, but no intera...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Busetto, Virginia, Barbosa, Isabelle, Basquin, Jérôme, Marquenet, Émelie, Hocq, Rémi, Hennion, Magali, Paternina, Janio Antonio, Namane, Abdelkader, Conti, Elena, Bensaude, Olivier, Le Hir, Hervé
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
RNA and RNA-protein complexes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261170/
https://ncbi.nlm.nih.gov/pubmed/32329775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa267
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