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Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes
Human CWC27 is an uncharacterized splicing factor and mutations in its gene are linked to retinal degeneration and other developmental defects. We identify the splicing factor CWC22 as the major CWC27 partner. Both CWC27 and CWC22 are present in published B(act) spliceosome structures, but no intera...
Shranjeno v:
| izdano v: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7261170/ https://ncbi.nlm.nih.gov/pubmed/32329775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa267 |
| Oznake: |
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