Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs. Indeed, statins are in a wide medical use, yet statins treatment could induce side e...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Cirigliano, Angela, Amelina, Antonia, Biferali, Beatrice, Macone, Alberto, Mozzetta, Chiara, Bianchi, Michele Maria, Mori, Mattia, Botta, Bruno, Pick, Elah, Negri, Rodolfo, Rinaldi, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844431/
https://ncbi.nlm.nih.gov/pubmed/31694426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1687461
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