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Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury

The pathology of acute lung injury (ALI) involves inducible nitric oxide (NO) synthase (iNOS)-derived NO-induced apoptosis of pulmonary endothelial cells. In vitro, iNOS-derived NO production has been shown to depend on the uptake of l-arginine by the cationic amino acid transporters (CAT). To test...

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Publicado en:Am J Physiol Lung Cell Mol Physiol
Main Authors: Jin, Yi, Liu, Yusen, Nelin, Leif D.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842872/
https://ncbi.nlm.nih.gov/pubmed/30628488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00223.2018
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