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Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination

In order to produce effective antibodies, B cells undergo rapid somatic hypermutation (SHM) and selection for binding affinity to antigen via a process called affinity maturation. The similarities between this process and evolution by natural selection have led many groups to use phylogenetic method...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Hoehn, Kenneth B., Vander Heiden, Jason A., Zhou, Julian Q., Lunter, Gerton, Pybus, Oliver G., Kleinstein, Steven H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842591/
https://ncbi.nlm.nih.gov/pubmed/31636219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906020116
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