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A Phylogenetic Codon Substitution Model for Antibody Lineages

Phylogenetic methods have shown promise in understanding the development of broadly neutralizing antibody lineages (bNAbs). However, the mutational process that generates these lineages, somatic hypermutation, is biased by hotspot motifs which violates important assumptions in most phylogenetic subs...

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Bibliografski detalji
Izdano u:Genetics
Glavni autori: Hoehn, Kenneth B., Lunter, Gerton, Pybus, Oliver G.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419485/
https://ncbi.nlm.nih.gov/pubmed/28315836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.196303
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