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A Phylogenetic Codon Substitution Model for Antibody Lineages
Phylogenetic methods have shown promise in understanding the development of broadly neutralizing antibody lineages (bNAbs). However, the mutational process that generates these lineages, somatic hypermutation, is biased by hotspot motifs which violates important assumptions in most phylogenetic subs...
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| Veröffentlicht in: | Genetics |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Genetics Society of America
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5419485/ https://ncbi.nlm.nih.gov/pubmed/28315836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.196303 |
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