Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1

BACKGROUND: Paclitaxel is a widely used and potent chemotherapeutic agent for the treatment of cancer. However, patients receiving paclitaxel often develop an acute pain syndrome for which there are few treatment options. Astrocytes play an important role in the pathogenesis of pain in multiple prec...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Liu, Xiaojuan, Tonello, Raquel, Ling, Yuejuan, Gao, Yong-Jing, Berta, Temugin
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842526/
https://ncbi.nlm.nih.gov/pubmed/31707979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1619-9
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